Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak

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Theingi Win Myat Hlaing Myat Thu Hlaing Mya Win Khin Saw Than Zaw Than Tun Khin Mar Aye Nila Zaw Khin Sandar Aye Kyaw Zin Thant

Abstract

During the 2015 dengue season in Myanmar, there was an unusual increase in occurrence of adult dengue cases. To identify circulating serotypes and clinical profiles of adult dengue during the outbreak, blood samples were collected from clinically suspected dengue patients admitted to Yangon General Hospital during July to September 2015. Among 75 samples tested for NS1Ag and immunoglobulins IgG/IgM, 33 (44.0%) were serologically confirmed, including 11 (33.3%) primary and 22 (66.7%) secondary infection. The mean age was 20.8 years (range 13-49 years). There were 77.3% (17/22) of secondary infection and 45.5% (5/11) of primary infection developed into severe types of dengue infection. Bleeding manifestations occurred in 13 (39.4%) patients, with gastrointestinal bleeding as the most common form. Out of the 33 samples serologically confirmed, dengue virus was detected in six (18.2%) and all were serotype 1 which has been the predominant serotype in Myanmar since 2009. These findings contributed information on the recent adult dengue outbreak and aided to bridge the knowledge gap concerning adult dengue in Myanmar. Further molecular research should be conducted on serotype negative samples.


Keywords: dengue outbreak, adult dengue, dengue virus serotypes, Myanmar


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MYAT, Theingi Win et al. Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak. OSIR Journal, [S.l.], v. 10, n. 2, p. 8-13, june 2017. ISSN 2286-8933. Available at: <http://www.osirjournal.net/index.php/osir/article/view/101>. Date accessed: 19 sep. 2017.
Myat, ...., Thu, ...., Win, ...., Than, ...., Tun, ...., Aye, ...., Zaw, ...., Aye, ...., & Thant, .... (2017). Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak. OSIR Journal, 10(2), 8-13. Retrieved from http://www.osirjournal.net/index.php/osir/article/view/101
Myat, ...., Thu, ...., Win, ...., Than, ...., Tun, ...., Aye, ...., Zaw, ...., Aye, ...., & Thant, .... 2017 Jun 29. Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak. OSIR Journal. [Online] 10:2
%A Myat, Theingi Win %A Thu, Hlaing Myat %A Win, Hlaing Mya %A Than, Khin Saw %A Tun, Zaw Than %A Aye, Khin Mar %A Zaw, Nila %A Aye, Khin Sandar %A Thant, Kyaw Zin %D 2017 %T Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak %B 2017 %9 %! Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak %K %X During the 2015 dengue season in Myanmar, there was an unusual increase in occurrence of adult dengue cases. To identify circulating serotypes and clinical profiles of adult dengue during the outbreak, blood samples were collected from clinically suspected dengue patients admitted to Yangon General Hospital during July to September 2015. Among 75 samples tested for NS1Ag and immunoglobulins IgG/IgM, 33 (44.0%) were serologically confirmed, including 11 (33.3%) primary and 22 (66.7%) secondary infection. The mean age was 20.8 years (range 13-49 years). There were 77.3% (17/22) of secondary infection and 45.5% (5/11) of primary infection developed into severe types of dengue infection. Bleeding manifestations occurred in 13 (39.4%) patients, with gastrointestinal bleeding as the most common form. Out of the 33 samples serologically confirmed, dengue virus was detected in six (18.2%) and all were serotype 1 which has been the predominant serotype in Myanmar since 2009. These findings contributed information on the recent adult dengue outbreak and aided to bridge the knowledge gap concerning adult dengue in Myanmar. Further molecular research should be conducted on serotype negative samples. Keywords: dengue outbreak, adult dengue, dengue virus serotypes, Myanmar %U http://www.osirjournal.net/index.php/osir/article/view?path= %J OSIR Journal %0 Journal Article %& 8 %P 6 %V 10 %N 2 %@ 2286-8933 %8 2017-06-29 %7 2017-06-29
Myat, Theingi Win, Hlaing Myat Thu, Hlaing Mya Win, Khin Saw Than, Zaw Than Tun, Khin Mar Aye, Nila Zaw, Khin Sandar Aye, & Kyaw Zin Thant. "Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak." OSIR Journal [Online], 10.2 (2017): 8-13. Web. 19 Sep. 2017
TY - JOUR AU - Myat, Theingi Win AU - Thu, Hlaing Myat AU - Win, Hlaing Mya AU - Than, Khin Saw AU - Tun, Zaw Than AU - Aye, Khin Mar AU - Zaw, Nila AU - Aye, Khin Sandar AU - Thant, Kyaw Zin PY - 2017 TI - Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak JF - OSIR Journal; Volume 10 Issue 2 ( 2017 ): Outbreak, Surveillance and Investigation Reports KW - N2 - During the 2015 dengue season in Myanmar, there was an unusual increase in occurrence of adult dengue cases. To identify circulating serotypes and clinical profiles of adult dengue during the outbreak, blood samples were collected from clinically suspected dengue patients admitted to Yangon General Hospital during July to September 2015. Among 75 samples tested for NS1Ag and immunoglobulins IgG/IgM, 33 (44.0%) were serologically confirmed, including 11 (33.3%) primary and 22 (66.7%) secondary infection. The mean age was 20.8 years (range 13-49 years). There were 77.3% (17/22) of secondary infection and 45.5% (5/11) of primary infection developed into severe types of dengue infection. Bleeding manifestations occurred in 13 (39.4%) patients, with gastrointestinal bleeding as the most common form. Out of the 33 samples serologically confirmed, dengue virus was detected in six (18.2%) and all were serotype 1 which has been the predominant serotype in Myanmar since 2009. These findings contributed information on the recent adult dengue outbreak and aided to bridge the knowledge gap concerning adult dengue in Myanmar. Further molecular research should be conducted on serotype negative samples. Keywords: dengue outbreak, adult dengue, dengue virus serotypes, Myanmar UR - http://www.osirjournal.net/index.php/osir/article/view?path=
TY - JOUR AU - Myat, Theingi Win AU - Thu, Hlaing Myat AU - Win, Hlaing Mya AU - Than, Khin Saw AU - Tun, Zaw Than AU - Aye, Khin Mar AU - Zaw, Nila AU - Aye, Khin Sandar AU - Thant, Kyaw Zin PY - 2017/06/29/ TI - Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak JF - OSIR Journal; Volume<font color=red> 10</font> Issue<font color=red> 2</font> (<font color=#33ff33>2017</font>): Outbreak, Surveillance and Investigation Reports KW - N2 - During the 2015 dengue season in Myanmar, there was an unusual increase in occurrence of adult dengue cases. To identify circulating serotypes and clinical profiles of adult dengue during the outbreak, blood samples were collected from clinically suspected dengue patients admitted to Yangon General Hospital during July to September 2015. Among 75 samples tested for NS1Ag and immunoglobulins IgG/IgM, 33 (44.0%) were serologically confirmed, including 11 (33.3%) primary and 22 (66.7%) secondary infection. The mean age was 20.8 years (range 13-49 years). There were 77.3% (17/22) of secondary infection and 45.5% (5/11) of primary infection developed into severe types of dengue infection. Bleeding manifestations occurred in 13 (39.4%) patients, with gastrointestinal bleeding as the most common form. Out of the 33 samples serologically confirmed, dengue virus was detected in six (18.2%) and all were serotype 1 which has been the predominant serotype in Myanmar since 2009. These findings contributed information on the recent adult dengue outbreak and aided to bridge the knowledge gap concerning adult dengue in Myanmar. Further molecular research should be conducted on serotype negative samples. Keywords: dengue outbreak, adult dengue, dengue virus serotypes, Myanmar UR - http://www.osirjournal.net/index.php/osir/article/view?path=
Myat, Theingi Win, Thu, Hlaing Myat, Win, Hlaing Mya, Than, Khin Saw, Tun, Zaw Than, Aye, Khin Mar, Zaw, Nila, Aye, Khin Sandar, AND Thant, Kyaw Zin. "Clinical Profile and Circulating Dengue Virus Serotype among Adults Admitted to Yangon General Hospital during the 2015 Dengue Outbreak" OSIR Journal [Online], Volume 10 Number 2 (29 June 2017)